منابع مشابه
Emerging Drug Therapies for Heart Failure
Heart failure is associated with high morbidity and mortality and is proving to be an economic burden in developing countries. A number of therapeutic agents are presently employed in heart failure; but they are not sufficient to control symptoms of heart failure. Moreover, the prevalence of chronic heart failure is progressively increasing and thus there is a continuing need to develop effecti...
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Randomized trials that affect regulatory approval, guideline, and third party payer considerations in patients with cardiovascular disease have increasingly required a relatively large number of patients and reliance upon geographic locations around the world. The reasons for inclusion of geographic locations around the world in these large-scale studies varies but, in general, these are relate...
متن کاملUltrafiltration Therapy for Heart Failure: Trials and Tribulations
Heart failure remains the leading cause of hospitalization in older patients and is considered a growing public health problem with a significant financial burden on the health care system. The suboptimal efficacy and safety profile of diuretic-based therapeutic regimens coupled with unsatisfactory results of the studies on novel pharmacologic agents have positioned ultrafiltration on the foref...
متن کاملEnd points for clinical trials in acute heart failure syndromes.
Acute heart failure syndromes (AHFS) remain a major cause of morbidity and mortality, in part because the development of new therapies for these disorders has been marked by frequent failure and little success. The heterogeneity of current approaches to AHFS drug development, particularly with regard to end points, remains a major potential barrier to progress in the field. End points involving...
متن کاملCardiorenal syndrome: ultrafiltration therapy for heart failure--trials and tribulations.
Heart failure remains the leading cause of hospitalization in older patients and is considered a growing public health problem with a significant financial burden on the health care system. The suboptimal efficacy and safety profile of diuretic-based therapeutic regimens coupled with unsatisfactory results of the studies on novel pharmacologic agents have positioned ultrafiltration on the foref...
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ژورنال
عنوان ژورنال: Clinical Cardiology
سال: 1994
ISSN: 0160-9289,1932-8737
DOI: 10.1002/clc.4960171102